Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During C. elegans Vulval Development-Reference-Cited by-同舟云学术

Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During C. elegans Vulval Development

Published:2001-02-09 Issue:5506 Volume:291 Page:1055-1058
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Berset Thomas¹,Hoier Erika Fröhli¹,Battu Gopal¹,Canevascini Stefano¹,Hajnal Alex¹

Affiliation:

1. Division of Cancer Research, Department of Pathology, University of Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.

Abstract

During Caenorhabditis elegans vulval development, a signal from the anchor cell stimulates the RTK/RAS/MAPK (receptor tyrosine kinase/RAS/mitogen-activated protein kinase) signaling pathway in the closest vulval precursor cell P6.p to induce the primary fate. A lateral signal from P6.p then activates the Notch signaling pathway in the neighboring cells P5.p and P7.p to prevent them from adopting the primary fate and to specify the secondary fate. The MAP kinase phosphatase LIP-1 mediates this lateral inhibition of the primary fate. LIN-12/NOTCH up-regulates lip-1 transcription in P5.p and P7.p where LIP-1 inactivates the MAP kinase to inhibit primary fate specification. LIP-1 thus links the two signaling pathways to generate a pattern.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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2. For details on the materials and methods used see the supplementary information on Science Online at www.sciencemag.org/cgi/content/full/291/5506/1055/DC1.

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