Specifying and Sustaining Pigmentation Patterns in Domestic and Wild Cats

Author:

Kaelin Christopher B.12,Xu Xiao34,Hong Lewis Z.2,David Victor A.3,McGowan Kelly A.2,Schmidt-Küntzel Anne35,Roelke Melody E.36,Pino Javier7,Pontius Joan36,Cooper Gregory M.1,Manuel Hermogenes2,Swanson William F.8,Marker Laurie5,Harper Cindy K.9,van Dyk Ann10,Yue Bisong4,Mullikin James C.11,Warren Wesley C.12,Eizirik Eduardo1314,Kos Lidia7,O’Brien Stephen J.3,Barsh Gregory S.12,Menotti-Raymond Marilyn3

Affiliation:

1. HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.

2. Department of Genetics, Stanford University, Stanford, CA, 94305, USA.

3. Laboratory of Genomic Diversity, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

4. Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Sichuan 610064, China.

5. Cheetah Conservation Fund, Post Office Box 1755, Otjiwarongo, Namibia.

6. SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

7. Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.

8. Center for Conservation and Research of Endangered Wildlife, Cincinnati Zoo & Botanical Garden, Cincinnati, OH 45220, USA.

9. Veterinary Genetics Laboratory, Faculty of Veterinary Science Onderstepoort, University of Pretoria, Pretoria, South Africa.

10. The Ann van Dyk Cheetah Centre, De Wildt, South Africa.

11. Comparative Genomics Unit, National Human Genome Research Institute, National Institutes of Health, Rockville, MD 20892, USA.

12. The Genome Center, Washington University in St. Louis, St. Louis, MO 63108, USA.

13. Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.

14. Instituto Pró-Carnívoros, Atibaia, Brazil.

Abstract

What Kitty Shares with Kings Although long-studied, the underlying basis of mammalian coat patterns remains unclear. By studying a large number of cat species and varieties, Kaelin et al. (p. 1536 ) identified two genes, Taqpep and Edn3 , as critical factors in the development of feline pigment patterns. Mutations in Taqpep are responsible for the blotched tabby pattern in domestic cats and the unusual coat of wild king cheetahs. Gene expression patterns in cat and cheetah skin suggest that Edn3 is a likely regulator of felid hair color. The findings support a common model for coat and pigment pattern formation in domestic and wild cats.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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