Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

Author:

Pfeifer Alexander1,Aszódi Attila2,Seidler Ursula3,Ruth Peter1,Hofmann Franz1,Fässler Reinhard2

Affiliation:

1. A. Pfeifer, P. Ruth, F. Hofmann, Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Strasse 29, D-80802 München, Germany.

2. A. Aszódi and R. Fässler, Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany.

3. U. Seidler, Medizinische Klinik I, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, Germany.

Abstract

Cyclic guanosine 3′,5′-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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