Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II-Reference-Cited by-同舟云学术

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

Published:1996-12-20 Issue:5295 Volume:274 Page:2082-2086
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pfeifer Alexander¹,Aszódi Attila²,Seidler Ursula³,Ruth Peter¹,Hofmann Franz¹,Fässler Reinhard²

Affiliation:

1. A. Pfeifer, P. Ruth, F. Hofmann, Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Strasse 29, D-80802 München, Germany.

2. A. Aszódi and R. Fässler, Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany.

3. U. Seidler, Medizinische Klinik I, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, Germany.

Abstract

Cyclic guanosine 3′,5′-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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