Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice-Reference-Cited by-同舟云学术

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

Published:2018-03-23 Issue:6382 Volume:359 Page:1403-1407
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pereira Ethel R.¹^ORCID,Kedrin Dmitriy¹²^ORCID,Seano Giorgio¹^ORCID,Gautier Olivia¹³^ORCID,Meijer Eelco F. J.¹^ORCID,Jones Dennis¹^ORCID,Chin Shan-Min¹^ORCID,Kitahara Shuji¹^ORCID,Bouta Echoe M.¹^ORCID,Chang Jonathan⁴⁵^ORCID,Beech Elizabeth¹,Jeong Han-Sin⁶^ORCID,Carroll Michael C.⁵⁷^ORCID,Taghian Alphonse G.⁸,Padera Timothy P.¹^ORCID

Affiliation:

1. Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.

2. Division of Gastroenterology, MGH and HMS, Boston, MA 02114, USA.

3. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Graduate Program in Immunology, Division of Medical Sciences, HMS, Boston, MA 02115, USA.

5. Program in Cellular and Molecular Medicine, Children’s Hospital Boston and HMS, Boston, MA 02115, USA.

6. Department of Otorhinolaryngology and Head and Neck Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

7. Department of Pediatrics, Children’s Hospital Boston and HMS, Boston, MA 02115 USA.

8. Department of Radiation Oncology, MGH and HMS, Boston, MA 02114, USA.

Abstract

An alternate route for metastatic cells Metastatic tumor cells are thought to reach distant organs by traveling through the blood circulation or the lymphatic system. Two studies of mouse models now suggest a hybrid route for tumor cell dissemination. Pereira et al. and Brown et al. used distinct methodologies to monitor the fate of tumor cells in lymph nodes. They found that tumor cells could invade local blood vessels within a node, exit the node by entering the blood circulation, then go on to colonize the lung. Whether this dissemination route occurs in cancer patients is unknown; the answer could potentially change the way that affected lymph nodes are treated in cancer. Science , this issue p. 1403 , p. 1408

Funder

National Institutes of Health

Burroughs Wellcome Fund

Massachusetts General Hospital

Korean MEST

Samsung Biomedical Research Institute

Susan G. Komen for the Cure

United Negro College Fund Special Programs Corporation-Merck

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary