The Tetrameric Structure of a Glutamate Receptor Channel-Reference-Cited by-同舟云学术

The Tetrameric Structure of a Glutamate Receptor Channel

Published:1998-06-05 Issue:5369 Volume:280 Page:1596-1599
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rosenmund Christian¹²³,Stern-Bach Yael¹²³,Stevens Charles F.¹²³

Affiliation:

1. C. Rosenmund, Workgroup Cellular Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.

2. Y. Stern-Bach, The Hebrew University–Hadassah Dental School, Department of Anatomy and Embryology, Post Office Box 12272, Jerusalem, Israel.

3. C. F. Stevens, Howard Hughes Medical Institute, The Salk Institute, La Jolla, CA 92037, USA.

Abstract

The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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