Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations-Reference-Cited by-同舟云学术

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

Published:2002-05-31 Issue:5573 Volume:296 Page:1627-1630
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Friedberg Errol C.¹,Wagner Robert²,Radman Miroslav³

Affiliation:

1. Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2. Gene Check Inc., 1629 Blue Spruce Drive, Fort Collins, CO 80524, USA.

3. Evolutionary and Medical Molecular Genetics, INSERM E9916, Medical Faculty Necker–Enfants Malades, University of Paris-V, 156 Rue de Vaugirard, 75730 Paris Cedex 15, France.

Abstract

Cell death caused by arrested replication of damaged or structurally altered DNA can be avoided in prokaryotic and eukaryotic cells by multiple DNA polymerases that are specialized to bypass DNA damage. Some of these polymerases perform such translesion DNA synthesis of specific types of damage with high genetic fidelity. However, they exhibit greatly reduced fidelity when they operate on undamaged DNA or on DNA with lesions that are (apparently) not cognate substrates. The low fidelity of some of these specialized polymerases when copying undamaged DNA may be physiologically functional, including generating immunoglobulin diversity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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