Molecular architecture of the inner ring scaffold of the human nuclear pore complex-Reference-Cited by-同舟云学术

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

Published:2016-04-15 Issue:6283 Volume:352 Page:363-365
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kosinski Jan¹,Mosalaganti Shyamal¹,von Appen Alexander¹,Teimer Roman²,DiGuilio Amanda L.³,Wan William¹,Bui Khanh Huy⁴,Hagen Wim J.H.¹,Briggs John A. G.¹⁵,Glavy Joseph S.³,Hurt Ed²,Beck Martin¹⁵

Affiliation:

1. Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

2. Biochemistry Center of Heidelberg University, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.

3. Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, 507 River Street, Hoboken, NJ 07030, USA.

4. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.

5. Cell Biology and Biophysics Unit, EMBL, Heidelberg, Germany.

Abstract

Blueprint for a macromolecular machine Nuclear pore complexes (NPCs) consist of around 1000 protein subunits, are embedded in the membrane that surrounds the nucleus, and regulate transport between the nucleus and the cytoplasm. Although the overall shape of NPCs is known, the details of this macromolecular complex have been obscure. Now, Lin et al. have reconstituted the pore components, determined the interactions between them, and fitted them into a tomographic reconstruction. Kosinski et al. have provided an architectural map of the inner ring of the pore. Science , this issue pp. 10.1126/science.aaf1015 and 363

Funder

Stevens Institute of Technology

National Institute on Aging (NIA)

Ignition Grant Initiative from Stevens Institute of Technology

NIA

EMBL

European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.