Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells-Reference-Cited by-同舟云学术

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

Published:2014-05-02 Issue:6183 Volume:344 Page:527-532
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Larrieu Delphine¹,Britton Sébastien¹,Demir Mukerrem¹,Rodriguez Raphaël²,Jackson Stephen P.¹³

Affiliation:

1. The Wellcome Trust/Cancer Research UK (CRUK) Gurdon Institute and Department of Biochemistry, University of Cambridge, CB2 1QN Cambridge, UK.

2. Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France.

3. The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.

Abstract

Remodelin Nuclear Defects Deregulation of A-type lamin proteins leads to disorganization of chromatin structure and misshapen nuclei, which are believed to underlie the pathologies of various human diseases, including the premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) and various cancers. Larrieu et al. (p. 527 ) developed a small molecule, Remodelin, that not only improved nuclear shape defects of human lamin A/C–depleted cells, HGPS cells, and aged normal cells, but also decreased the levels of a DNA damage marker and improved global cellular fitness.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

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4. Nuclear A-type lamins are differentially expressed in human lung cancer subtypes;Broers J. L.;Am. J. Pathol.,1993

5. Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms

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