Construction and Analysis of a Human-Chimpanzee Comparative Clone Map-Reference-Cited by-同舟云学术

Construction and Analysis of a Human-Chimpanzee Comparative Clone Map

Published:2002-01-04 Issue:5552 Volume:295 Page:131-134
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fujiyama Asao¹²,Watanabe Hidemi¹,Toyoda Atsushi¹,Taylor Todd D.¹,Itoh Takehiko³,Tsai Shih-Feng⁴⁵,Park Hong-Seog⁶,Yaspo Marie-Laure⁷,Lehrach Hans⁷,Chen Zhu⁸,Fu Gang⁸,Saitou Naruya²,Osoegawa Kazutoyo⁹,de Jong Pieter J.⁹,Suto Yumiko¹⁰,Hattori Masahira¹,Sakaki Yoshiyuki¹¹¹

Affiliation:

1. RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

2. National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8450, Japan.

3. Mitsubishi Research Institute, 3-6, Otemachi 2-chome Chiyoda-ku, Tokyo 100-8141, Japan.

4. National Yang-Ming University, 128, Yen-chiu, Yuan Road, Sec. 2, Taipei 115, Taiwan.

5. National Health Research Institutes, 128, Yen-chiu, Yuan Road, Sec. 2, Taipei 115, Taiwan.

6. Genome Research Center, KRIBB, 52 Oun-dong, Yusong-gu, Daejeon 305-333, Korea.

7. Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin-Dahlem, Germany.

8. Chinese National Human Genome Center at Shanghai, 351, Guo Shou Jing Road, Shanghai 201203, China.

9. Children's Hospital Oakland Research Institute, BACPAC Resources, 747 52nd Street, Oakland, CA 94609–1809, USA.

10. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongou, Bunkyou-ku, Tokyo 113-0033, Japan.

11. Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Abstract

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

1. International Human Genome Sequencing consortium Nature 409 860 (2001).

2. The Sequence of the Human Genome

3. Evolution at Two Levels in Humans and Chimpanzees

4. Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.

5. Chromosomal evolution in Primates: Tentative phylogeny from Microcebus murinus (Prosimian) to man

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