Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network

Author:

Mukhtar M. Shahid1,Carvunis Anne-Ruxandra234,Dreze Matija235,Epple Petra1,Steinbrenner Jens6,Moore Jonathan7,Tasan Murat8,Galli Mary9,Hao Tong23,Nishimura Marc T.1,Pevzner Samuel J.231011,Donovan Susan E.6,Ghamsari Lila23,Santhanam Balaji23,Romero Viviana23,Poulin Matthew M.23,Gebreab Fana23,Gutierrez Bryan J.23,Tam Stanley23,Monachello Dario12,Boxem Mike13,Harbort Christopher J.1,McDonald Nathan1,Gai Lantian9,Chen Huaming9,He Yijian1,Vandenhaute Jean5,Roth Frederick P.28,Hill David E.23,Ecker Joseph R.914,Vidal Marc23,Beynon Jim67,Braun Pascal23,Dangl Jeffery L.1151617,

Affiliation:

1. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

3. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

4. Computational and Mathematical Biology Group, TIMC-IMAG, CNRS UMR5525 and Université de Grenoble, Faculté de Médecine, 38706 La Tronche cedex, France.

5. Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Wallonia-Brussels Federation, Belgium.

6. School of Life Sciences, University of Warwick, Wellesbourne, Warwick, CV35 9EF, UK.

7. Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry, CV4 7AL, UK.

8. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

9. Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

10. Biomedical Engineering Department, Boston University, Boston, MA 02215, USA.

11. Boston University School of Medicine, Boston, MA 02118, USA.

12. Unité Mixte de Recherche en Génomique Végétale (URGV), UMR, Institut National de la Recherche Agronomique (INRA), Université d’Evry–Val d'Essonne—European Research Laboratory (UEVE–ERL), CNRS, 91057 Evry Cedex, France.

13. Utrecht University, 3584 CH Utrecht, Netherlands.

14. Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

15. Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

16. Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

17. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

An analysis of protein-protein interactions in Arabidopsis identifies the plant interactome.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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