Intravital imaging of mouse embryos-Reference-Cited by-同舟云学术

Intravital imaging of mouse embryos

Published:2020-04-10 Issue:6487 Volume:368 Page:181-186
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Huang Qiang¹²^ORCID,Cohen Malkiel A.³^ORCID,Alsina Fernando C.⁴^ORCID,Devlin Garth⁵,Garrett Aliesha²^ORCID,McKey Jennifer⁶^ORCID,Havlik Patrick⁵,Rakhilin Nikolai²,Wang Ergang²^ORCID,Xiang Kun²^ORCID,Mathews Parker⁷,Wang Lihua²,Bock Cheryl⁸,Ruthig Victor⁶^ORCID,Wang Yi²^ORCID,Negrete Marcos²^ORCID,Wong Chi Wut²^ORCID,Murthy Preetish K. L.²^ORCID,Zhang Shupei³,Daniel Andrea R.⁹^ORCID,Kirsch David G.⁹¹⁰^ORCID,Kang Yubin⁷^ORCID,Capel Blanche⁶^ORCID,Asokan Aravind⁵^ORCID,Silver Debra L.⁴^ORCID,Jaenisch Rudolf³¹¹^ORCID,Shen Xiling²^ORCID

Affiliation:

1. Department of Pediatric Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China.

2. Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA.

3. Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

4. Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA.

5. Department of Surgery, School of Medicine, Duke University, Durham, NC, USA.

6. Department of Cell Biology, School of Medicine, Duke University, Durham, NC, USA.

7. Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.

8. Duke Cancer Institute, School of Medicine, Duke University, Durham, NC, USA.

9. Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.

10. Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC, USA.

11. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

A window to the embryo Mammalian embryonic development is a complex process, continuously changing in space and time. Q. Huang et al. designed an abdominal window to image mouse embryos in utero from embryonic day 9.5 to birth. Using this technique, they visualized dynamic activities during embryonic organ formation, including neurotransmission and cell division in the brain, autophagy in the retina, viral gene delivery, and placental drug transfer. They also tracked diverging fates of human and mouse neural crest cells in interspecies chimeras. Science , this issue p. 181

Funder

National Institute of General Medical Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Technicolour transgenics: imaging tools for functional genomics in the mouse

2. Pten is essential for embryonic development and tumour suppression

3. Quantitative in vivo imaging of embryonic development: Opportunities and challenges

4. Advances in whole-embryo imaging: a quantitative transition is underway

5. In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level

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