Predictive grid coding in the medial entorhinal cortex

Author:

Ouchi Ayako1ORCID,Fujisawa Shigeyoshi12ORCID

Affiliation:

1. Laboratory for Systems Neurophysiology, RIKEN Center for Brain Science, Wako City, Saitama 351-0198, Japan.

2. Department of Complexity Science and Engineering, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan.

Abstract

The entorhinal cortex represents allocentric spatial geometry and egocentric speed and heading information required for spatial navigation. However, it remains unclear whether it contributes to the prediction of an animal’s future location. We discovered grid cells in the medial entorhinal cortex (MEC) that have grid fields representing future locations during goal-directed behavior. These predictive grid cells represented prospective spatial information by shifting their grid fields against the direction of travel. Predictive grid cells discharged at the trough phases of the hippocampal CA1 theta oscillation and, together with other types of grid cells, organized sequences of the trajectory from the current to future positions across each theta cycle. Our results suggest that the MEC provides a predictive map that supports forward planning in spatial navigation.

Publisher

American Association for the Advancement of Science (AAAS)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Mapping future locations;Nature Reviews Neuroscience;2024-09-02

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