Transcriptomic cytoarchitecture reveals principles of human neocortex organization-Reference-Cited by-同舟云学术

Transcriptomic cytoarchitecture reveals principles of human neocortex organization

Published:2023-10-13 Issue:6667 Volume:382 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jorstad Nikolas L.¹^ORCID,Close Jennie¹^ORCID,Johansen Nelson¹^ORCID,Yanny Anna Marie¹,Barkan Eliza R.¹^ORCID,Travaglini Kyle J.¹^ORCID,Bertagnolli Darren¹^ORCID,Campos Jazmin¹^ORCID,Casper Tamara¹^ORCID,Crichton Kirsten¹^ORCID,Dee Nick¹^ORCID,Ding Song-Lin¹^ORCID,Gelfand Emily¹^ORCID,Goldy Jeff¹^ORCID,Hirschstein Daniel¹,Kiick Katelyn¹^ORCID,Kroll Matthew¹,Kunst Michael¹^ORCID,Lathia Kanan¹^ORCID,Long Brian¹^ORCID,Martin Naomi¹^ORCID,McMillen Delissa¹^ORCID,Pham Trangthanh¹^ORCID,Rimorin Christine¹^ORCID,Ruiz Augustin¹^ORCID,Shapovalova Nadiya¹^ORCID,Shehata Soraya¹^ORCID,Siletti Kimberly²^ORCID,Somasundaram Saroja¹^ORCID,Sulc Josef¹^ORCID,Tieu Michael¹^ORCID,Torkelson Amy¹^ORCID,Tung Herman¹^ORCID,Callaway Edward M.³^ORCID,Hof Patrick R.⁴^ORCID,Keene C. Dirk⁵^ORCID,Levi Boaz P.¹^ORCID,Linnarsson Sten²^ORCID,Mitra Partha P.⁶^ORCID,Smith Kimberly¹^ORCID,Hodge Rebecca D.¹^ORCID,Bakken Trygve E.¹^ORCID,Lein Ed S¹^ORCID

Affiliation:

1. Allen Institute for Brain Science, Seattle, WA 98109, USA.

2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.

3. Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

4. Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.

6. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA.

Abstract

Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We used single cell transcriptomics and performed cellular characterization of the human cortex to better understand cortical areal specialization. Single-nucleus RNA-sequencing of 8 areas spanning cortical structural variation showed a highly consistent cellular makeup for 24 cell subclasses. However, proportions of excitatory neuron subclasses varied substantially, likely reflecting differences in connectivity across primary sensorimotor and association cortices. Laminar organization of astrocytes and oligodendrocytes also differed across areas. Primary visual cortex showed characteristic organization with major changes in the excitatory to inhibitory neuron ratio, expansion of layer 4 excitatory neurons, and specialized inhibitory neurons. These results lay the groundwork for a refined cellular and molecular characterization of human cortical cytoarchitecture and areal specialization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adf6812

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