Structure-function analysis identifies highly sensitive strigolactone receptors in Striga

Author:

Toh Shigeo1,Holbrook-Smith Duncan1,Stogios Peter J.23,Onopriyenko Olena2,Lumba Shelley1,Tsuchiya Yuichiro4,Savchenko Alexei2,McCourt Peter1

Affiliation:

1. Cell and Systems Biology, University of Toronto, 25 Willcocks Street, Toronto M5S 3B2, Canada.

2. Department of Chemical Engineering and Applied Chemistry, Banting and Best Department of Medical Research, University of Toronto, 200 College Street, Toronto M5S 3E5, Canada.

3. Center for Structural Genomics of Infectious Diseases, contracted by National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

4. Institute of Transformative Bio-Molecules, Nagoya University, Japan, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8602, Japan.

Abstract

Striga uses a hypersensitive receptor The strigolactone hormones govern plant growth and development. A nasty parasitic weed, Striga , senses traces of these hormones to identify its targets. After functionally characterizing several strigolactone receptors from Striga , Toh et al. solved the crystal structure of one that is especially sensitive. The structure shows an unexpectedly large ligand-binding pocket, which may explain how Striga manages to sense picomolar concentrations of the range of strigolactones. Science , this issue p. 203

Funder

National Science and Engineering Research Council of Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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