Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

Author:

Zhernakova Alexandra12,Kurilshikov Alexander34,Bonder Marc Jan1,Tigchelaar Ettje F.12,Schirmer Melanie56,Vatanen Tommi57,Mujagic Zlatan28,Vila Arnau Vich9,Falony Gwen1011,Vieira-Silva Sara1011,Wang Jun1011,Imhann Floris9,Brandsma Eelke12,Jankipersadsing Soesma A.1,Joossens Marie101113,Cenit Maria Carmen11415,Deelen Patrick116,Swertz Morris A.116,Weersma Rinse K.9,Feskens Edith J. M.217,Netea Mihai G.18,Gevers Dirk5,Jonkers Daisy8,Franke Lude1,Aulchenko Yurii S.4192021,Huttenhower Curtis56,Raes Jeroen101113,Hofker Marten H.12,Xavier Ramnik J.5222324,Wijmenga Cisca1,Fu Jingyuan112,

Affiliation:

1. University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Netherlands.

2. Top Institute Food and Nutrition, Wageningen, Netherlands.

3. Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia.

4. Novosibirsk State University, Novosibirsk, Russia.

5. The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

6. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

7. Department of Computer Science, Aalto University School of Science, Espoo, Finland.

8. Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands.

9. University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands.

10. KU Leuven–University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, Leuven, Belgium.

11. VIB, Center for the Biology of Disease, Leuven, Belgium.

12. University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, Netherlands.

13. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium.

14. Microbial Ecology, Nutrition and Health Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.

15. Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain.

16. University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, Netherlands.

17. Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.

18. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

19. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.

20. PolyOmica, Groningen, Netherlands.

21. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.

22. Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.

23. Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, USA.

24. Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

“Normal” for the gut microbiota For the benefit of future clinical studies, it is critical to establish what constitutes a “normal” gut microbiome, if it exists at all. Through fecal samples and questionnaires, Falony et al. and Zhernakova et al. targeted general populations in Belgium and the Netherlands, respectively. Gut microbiota composition correlated with a range of factors including diet, use of medication, red blood cell counts, fecal chromogranin A, and stool consistency. The data give some hints for possible biomarkers of normal gut communities. Science , this issue pp. 560 and 565

Funder

Top Institute Food and Nutrition, Wageningen

Netherlands Organization for Scientific Research

CardioVasculair Onderzoek Nederland

European Research Council (ERC)

European Union's Seventh Framework Program

ERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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