Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF-Reference-Cited by-同舟云学术

Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF

Published:2023-07-21 Issue:6655 Volume:381 Page:302-306
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Patel Calum¹^ORCID,André-Joyaux Emy¹^ORCID,Leitch Jamie A.²³^ORCID,de Irujo-Labalde Xabier Martínez⁴^ORCID,Ibba Francesco¹³^ORCID,Struijs Job¹^ORCID,Ellwanger Mathias A.¹^ORCID,Paton Robert⁵^ORCID,Browne Duncan L.²^ORCID,Pupo Gabriele¹³^ORCID,Aldridge Simon¹^ORCID,Hayward Michael A.⁴^ORCID,Gouverneur Véronique¹^ORCID

Affiliation:

1. Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.

2. Department of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, London W1CN 1AX, UK.

3. FluoRok Ltd., Begbroke Science Park, Begbroke Hill, Woodstock Road, Begbroke OX5 1PF, UK.

4. Inorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, UK.

5. Department of Chemistry, Colorado State University, Fort Collins, CO 80528, USA.

Abstract

All fluorochemicals—including elemental fluorine and nucleophilic, electrophilic, and radical fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and corrosive gas is produced by the reaction of acid-grade fluorspar (>97% CaF 2 ) with sulfuric acid under harsh conditions. The use of fluorspar to produce fluorochemicals via a process that bypasses HF is highly desirable but remains an unsolved problem because of the prohibitive insolubility of CaF 2 . Inspired by calcium phosphate biomineralization, we herein disclose a protocol of treating acid-grade fluorspar with dipotassium hydrogen phosphate (K 2 HPO 4 ) under mechanochemical conditions. The process affords a solid composed of crystalline K 3 (HPO 4 )F and K 2− x Ca y (PO 3 F) a (PO 4 ) b , which is found suitable for forging sulfur-fluorine and carbon-fluorine bonds.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference99 articles.

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