Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response-Reference-Cited by-同舟云学术

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Published:2021-12-24 Issue:6575 Volume:374 Page:1632-1640
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Spencer Christine N.¹^ORCID,McQuade Jennifer L.²^ORCID,Gopalakrishnan Vancheswaran¹^ORCID,McCulloch John A.³^ORCID,Vetizou Marie³^ORCID,Cogdill Alexandria P.¹⁴^ORCID,Khan Md A. Wadud¹^ORCID,Zhang Xiaotao⁵^ORCID,White Michael G.¹^ORCID,Peterson Christine B.⁶^ORCID,Wong Matthew C.¹,Morad Golnaz¹^ORCID,Rodgers Theresa²^ORCID,Badger Jonathan H.³^ORCID,Helmink Beth A.¹,Andrews Miles C.¹⁷^ORCID,Rodrigues Richard R.⁸^ORCID,Morgun Andrey⁹^ORCID,Kim Young S.¹⁰,Roszik Jason²^ORCID,Hoffman Kristi L.¹¹^ORCID,Zheng Jiali⁵,Zhou Yifan⁴^ORCID,Medik Yusra B.⁴^ORCID,Kahn Laura M.⁴¹²^ORCID,Johnson Sarah¹^ORCID,Hudgens Courtney W.¹³^ORCID,Wani Khalida¹³,Gaudreau Pierre-Olivier¹⁴,Harris Angela L.¹⁵^ORCID,Jamal Mohamed A.¹⁶^ORCID,Baruch Erez N.¹⁷^ORCID,Perez-Guijarro Eva¹⁸^ORCID,Day Chi-Ping¹⁸^ORCID,Merlino Glenn¹⁸^ORCID,Pazdrak Barbara²^ORCID,Lochmann Brooke S.²^ORCID,Szczepaniak-Sloane Robert A.¹,Arora Reetakshi¹,Anderson Jaime²^ORCID,Zobniw Chrystia M.²^ORCID,Posada Eliza²,Sirmans Elizabeth²,Simon Julie¹^ORCID,Haydu Lauren E.¹^ORCID,Burton Elizabeth M.¹^ORCID,Wang Linghua¹⁶^ORCID,Dang Minghao¹⁶,Clise-Dwyer Karen¹⁹²⁰,Schneider Sarah¹⁹^ORCID,Chapman Thomas¹,Anang Nana-Ama A. S.⁴^ORCID,Duncan Sheila¹,Toker Joseph²¹²²,Malke Jared C.¹^ORCID,Glitza Isabella C.²^ORCID,Amaria Rodabe N.²,Tawbi Hussein A.²^ORCID,Diab Adi²^ORCID,Wong Michael K.²^ORCID,Patel Sapna P.²^ORCID,Woodman Scott E.²,Davies Michael A.²^ORCID,Ross Merrick I.¹,Gershenwald Jeffrey E.¹^ORCID,Lee Jeffrey E.¹^ORCID,Hwu Patrick²,Jensen Vanessa²³^ORCID,Samuels Yardena²⁴^ORCID,Straussman Ravid²⁴^ORCID,Ajami Nadim J.¹⁶^ORCID,Nelson Kelly C.²⁵^ORCID,Nezi Luigi²⁶^ORCID,Petrosino Joseph F.¹¹,Futreal P. Andrew¹⁶^ORCID,Lazar Alexander J.¹²¹⁶²⁷^ORCID,Hu Jianhua²⁸^ORCID,Jenq Robert R.¹⁶²⁹^ORCID,Tetzlaff Michael T.³⁰,Yan Yan³¹,Garrett Wendy S.³²^ORCID,Huttenhower Curtis³¹³³³⁴³⁵^ORCID,Sharma Padmanee⁴³⁶³⁷^ORCID,Watowich Stephanie S.⁴^ORCID,Allison James P.⁴³⁷^ORCID,Cohen Lorenzo³⁸,Trinchieri Giorgio³^ORCID,Daniel Carrie R.⁵^ORCID,Wargo Jennifer A.¹¹⁶^ORCID

Affiliation:

1. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3. Laboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

4. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

5. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

7. Department of Medicine, Monash University, Melbourne, VIC 3004, Australia.

8. Frederick National Laboratory for Cancer Research, and Microbiome and Genetics Core, Laboratory of Integrative Cancer Immunology, CCR, NCI, NIH, Bethesda, MD 20852, USA.

9. Department of Pharmaceutical Science, Oregon State University, Corvallis, OR 97331, USA.

10. Nutritional Science Research Group, Division of Cancer Prevention, NCI, NIH, Rockville, MD 20850, USA.

11. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

12. MD Anderson University of Texas Health Graduate School, Houston, TX 77030, USA.

13. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

14. Canadian Cancer Trials Group and Department of Oncology, Queen’s University, Kingston, ON K7L 3N6, Canada.

15. Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

16. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

17. Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA.

18. Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD 20892, USA.

19. Advanced Cytometry and Sorting Facility at South Campus, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

20. Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

21. Department of Neurosurgery, Harvard University, Cambridge, MA 02138, USA.

22. Department of Oncology, University of Cambridge, Cambridge CB2 1TN, UK.

23. Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

24. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.

25. Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

26. Dipartimento di Oncologia Sperimentale, Instituto Europeo di Oncologia, Milan, P.I. 08691440153, Italy.

27. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

28. Department of Biostatistics, Columbia University, New York, NY 10032, USA.

29. Department of Stem Cell Transplant, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

30. Departments of Pathology and Dermatology, Dermatopathology and Oral Pathology Unit, University of California San Francisco, San Francisco, CA 94115, USA.

31. Department of Biostatistics and the Harvard T.H. Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.

32. Department of Molecular Metabolism, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.

33. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

34. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

35. Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

36. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

37. Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

38. Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Another benefit of dietary fiber The gut microbiome can modulate the immune system and influence the therapeutic response of cancer patients, yet the mechanisms underlying the effects of microbiota are presently unclear. Spencer et al . add to our understanding of how dietary habits affect microbiota and clinical outcomes to immunotherapy. In an observational study, the researchers found that melanoma patients reporting high fiber (prebiotic) consumption had a better response to checkpoint inhibitor immunotherapy compared with those patients reporting a low-fiber diet. The most marked benefit was observed for those patients reporting a combination of high fiber consumption and no use of over-the-counter probiotic supplements. These findings provide early insights as to how diet-related factors may influence the immune response. —PNK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference74 articles.

1. Cancer immunotherapy using checkpoint blockade

2. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

3. The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

4. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

5. Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

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