Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins-Reference-Cited by-同舟云学术

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins

Published:2017-12-15 Issue:6369 Volume:358 Page:1431-1434
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lenarčič Tea¹^ORCID,Albert Isabell²^ORCID,Böhm Hannah²^ORCID,Hodnik Vesna¹³^ORCID,Pirc Katja¹,Zavec Apolonija B.¹,Podobnik Marjetka¹^ORCID,Pahovnik David⁴^ORCID,Žagar Ema⁴^ORCID,Pruitt Rory²,Greimel Peter⁵⁶,Yamaji-Hasegawa Akiko⁵⁷,Kobayashi Toshihide⁵⁸,Zienkiewicz Agnieszka⁹¹⁰^ORCID,Gömann Jasmin⁹¹⁰,Mortimer Jenny C.¹¹¹²^ORCID,Fang Lin¹¹¹²^ORCID,Mamode-Cassim Adiilah¹³,Deleu Magali¹⁴^ORCID,Lins Laurence¹⁴^ORCID,Oecking Claudia²^ORCID,Feussner Ivo⁹¹⁰^ORCID,Mongrand Sébastien¹³^ORCID,Anderluh Gregor¹^ORCID,Nürnberger Thorsten²^ORCID

Affiliation:

1. Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.

2. Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.

3. Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.

4. Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.

5. Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.

6. Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.

7. Molecular Membrane Neuroscience, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.

8. UMR 7213 CNRS, University of Strasbourg, 67401 Illkirch, France.

9. Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.

10. Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.

11. Joint Bioenergy Institute, Emeryville, CA 94608, USA.

12. Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

13. Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d’Ornon Cedex, France.

14. Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.

Abstract

An extra sugar protects Many microbial pathogens produce proteins that are toxic to the cells that they are targeting. Broad-leaved plants are susceptible to NLP (necrosis and ethylene-inducing peptide 1–like protein) toxins. Lenarčič et al. identified the receptors for NLP toxins to be GIPC (glycosylinositol phosphorylceramide) sphingolipids (see the Perspective by Van den Ackerveken). Their findings reveal why these toxins only attack broad-leaved plants (so-called eudicots): If the sphingolipid carries just two hexoses, as is the case for eudicots, the toxin binds and causes cell lysis. But in monocots with sphingolipids that have three hexoses, the toxin is ineffective. Science , this issue p. 1431 ; see also p. 1383

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Comparative and Functional Analysis of the Widely Occurring Family of Nep1-Like Proteins

2. Nep1-like proteins from plant pathogens: Recruitment and diversification of the NPP1 domain across taxa

3. A common toxin fold mediates microbial attack and plant defense

4. Phytotoxicity and Innate Immune Responses Induced by Nep1-Like Proteins

5. Disparate proteins use similar architectures to damage membranes

Cited by 169 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Plant and algal lipidomes: Analysis, composition, and their societal significance;Progress in Lipid Research;2024-11

2. ADP-ribosylation factor 1 (ARF1) protein interacts with elicitor PvNLP7 from Plasmopara viticola to mediate PvNLP7-triggered immunity;Plant Science;2024-10

3. Exploring lipid signaling in plant physiology: From cellular membranes to environmental adaptation;Journal of Plant Physiology;2024-09

4. The binding pattern of ferric iron and iron-binding protein in Botrytis cinerea;Computers in Biology and Medicine;2024-08

5. Sphingosine Promotes Fiber Early Elongation in Upland Cotton;Plants;2024-07-21