Negative selection in humans and fruit flies involves synergistic epistasis
Author:
Sohail Mashaal123ORCID, Vakhrusheva Olga A.4, Sul Jae Hoon5ORCID, Pulit Sara L.67ORCID, Francioli Laurent C.7, van den Berg Leonard H.6ORCID, Veldink Jan H.6, de Bakker Paul I. W.78ORCID, Bazykin Georgii A.49ORCID, Kondrashov Alexey S.1011ORCID, Sunyaev Shamil R.23ORCID, Menelaou Androniki, van Dijk Freerk, Palamara Pier Francesco, Elbers Clara C., Neerincx Pieter B.T., Ye Kai, Guryev Victor, Kloosterman Wigard P., Deelen Patrick, Abdellaoui Abdel, van Leeuwen Elisabeth M., van Oven Mannis, Vermaat Martijn, Li Mingkun, Laros Jeroen F.J., Karssen Lennart C., Kanterakis Alexandros, Amin Najaf, Hottenga Jouke Jan, Lameijer Eric-Wubbo, Kattenberg Mathijs, Dijkstra Martijn, Byelas Heorhiy, van Setten Jessica, van Schaik Barbera D.C., Bot Jan, Nijman Isac J., Renkens Ivo, Marschall Tobias, Schnhuth Alexander, Hehir-Kwa Jayne Y., Handsaker Robert E, Polak Paz, Vuzman Dana, Hormozdiari Fereydoun, van Enckevort David, Mei Hailiang, Koval Vyacheslav, Moed Matthijs H., Joeri van der Velde K., Rivadeneira Fernando, Estrada Karol, Medina-Gomez Carolina, Isaacs Aaron, McCarroll Steven A., Beekman Marian, de Craen Anton J.M., Suchiman H. Eka D., Hofman Albert, Oostra Ben, Uitterlinden Andr G., Willemsen Gonneke, Platteel Mathieu, Pitts Steven J., Potluri Shobha, Sundar Purnima, Cox David R., den Dunnen Johan T., Stoneking Mark, de Knijff Peter, Kayser Manfred, Li Qibin, Li Yingrui, Du Yuanping, Chen Ruoyan, Cao Hongzhi, Li Ning, Cao Sujie, Wang Jun, Bovenberg Jasper A., Pe’er Itsik, Slagboom P. Eline, van Duijn Cornelia M., Boomsma Dorret I., van Ommen Gert-Jan B, Swertz Morris A., Wijmenga Cisca, , ,
Affiliation:
1. Systems Biology PhD Program, Harvard Medical School, Boston, MA, USA. 2. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. 3. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 4. Institute for Information Transmission Problems (Kharkevich Institute) of the Russian Academy of Sciences, Moscow, Russia. 5. Department of Psychiatry and Biobehavioral Sciences, University of California–Los Angeles, Los Angeles, CA, USA. 6. Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. 7. Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, Netherlands. 8. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands. 9. Skolkovo Institute of Science and Technology, Skolkovo, Russia. 10. Department of Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, Moscow, Russia. 11. Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA.
Abstract
Ongoing selection against rare protein-disrupting mutations depends on an individual’s relative decline in fitness with each additional mutation.
Funder
National Institutes of Health Russian Science Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
103 articles.
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