The sheep genome illuminates biology of the rumen and lipid metabolism

Author:

Jiang Yu123,Xie Min4,Chen Wenbin4,Talbot Richard5,Maddox Jillian F.6,Faraut Thomas7,Wu Chunhua8,Muzny Donna M.9,Li Yuxiang4,Zhang Wenguang11011,Stanton Jo-Ann12,Brauning Rudiger13,Barris Wesley C.2,Hourlier Thibaut1415,Aken Bronwen L.1415,Searle Stephen M. J.14,Adelson David L.2,Bian Chao4,Cam Graham R.2,Chen Yulin3,Cheng Shifeng4,DeSilva Udaya2,Dixen Karen16,Dong Yang1,Fan Guangyi4,Franklin Ian R.2,Fu Shaoyin10,Fuentes-Utrilla Pablo5,Guan Rui4,Highland Margaret A.1718,Holder Michael E.9,Huang Guodong4,Ingham Aaron B.2,Jhangiani Shalini N.9,Kalra Divya9,Kovar Christie L.9,Lee Sandra L.9,Liu Weiqing4,Liu Xin4,Lu Changxin4,Lv Tian4,Mathew Tittu9,McWilliam Sean2,Menzies Moira2,Pan Shengkai4,Robelin David7,Servin Bertrand7,Townley David2,Wang Wenliang4,Wei Bin419,White Stephen N.1718,Yang Xinhua4,Ye Chen4,Yue Yaojing20,Zeng Peng4,Zhou Qing4,Hansen Jacob B.16,Kristiansen Karsten21,Gibbs Richard A.9,Flicek Paul15,Warkup Christopher C.22,Jones Huw E.22,Oddy V. Hutton23,Nicholas Frank W.24,McEwan John C.13,Kijas James W.2,Wang Jun4212526,Worley Kim C.9,Archibald Alan L.27,Cockett Noelle8,Xu Xun4,Wang Wen1,Dalrymple Brian P.2

Affiliation:

1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

2. Commonwealth Scientific and Industrial Research Organisation Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.

3. College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.

4. BGI-Shenzhen, Shenzhen 518083, China.

5. Ediburgh Genomics, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

6. Utah State University, Logan, UT 84322-4815, USA.

7. Institut National de la Recherche Agronomique, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.

8. Utah State University, Logan, UT 84322–1435, USA.

9. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

10. Inner Mongolia Agricultural University, Hohhot 010018, China.

11. Institute of ATCG, Nei Mongol Bio-Information, Hohhot, China.

12. Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.

13. AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.

14. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

15. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

16. Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.

17. U.S. Department of Agriculture Agricultural Research Service Animal Disease Research Unit, Pullman, WA 99164, USA.

18. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.

19. Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, China.

20. Lanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou, 730050, China.

21. Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

22. Biosciences Knowledge Transfer Network, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.

23. School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.

24. Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.

25. Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

26. Macau University of Science and Technology, Macau 999078, China.

27. The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

Abstract

A genome for ewe and ewe Sheep-specific genetic changes underlie differences in lipid metabolism between sheep and other mammals, and may have contributed to the production of wool. Jiang et al. sequenced the genome of two Texel sheep, a breed that produces high-value meat, milk, and wool. The genome information will provide an important resource for livestock production and aid in the understanding of mammalian evolution. Science , this issue p. 1168

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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