Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines-Reference-Cited by-同舟云学术

Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines

Published:1997-10-10 Issue:5336 Volume:278 Page:290-294
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Boshoff Chris¹²³⁴⁵,Endo Yoshio¹²³⁴⁵,Collins Paul D.¹²³⁴⁵,Takeuchi Yasuhiro¹²³⁴⁵,Reeves Jacqueline D.¹²³⁴⁵,Schweickart Vicki L.¹²³⁴⁵,Siani Michael A.¹²³⁴⁵,Sasaki Takuma¹²³⁴⁵,Williams Timothy J.¹²³⁴⁵,Gray Patrick W.¹²³⁴⁵,Moore Patrick S.¹²³⁴⁵,Chang Yuan¹²³⁴⁵,Weiss Robin A.¹²³⁴⁵

Affiliation:

1. C. Boshoff, Y. Takeuchi, J. D. Reeves, R. A. Weiss, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.

2. Y. Endo and T. Sasaki, Department of Experimental Therapeutics and Development Center for Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Japan.

3. P. D. Collins and T. J. Williams, Department of Applied Pharmacology, Imperial College School of Medicine at National Heart and Lung Institute, London SW3 6LY, UK.

4. V. L. Schweickart and P. W. Gray, ICOS, 22021 20th Avenue Southeast, Bothell, WA 98021, USA.

5. M. A. Siani, Gryphon Sciences, San Francisco, CA 94080, USA.

Abstract

Unique among known human herpesviruses, Kaposi's sarcoma–associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus–type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1α or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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