Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor-Reference-Cited by-同舟云学术

Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor

Published:1997-10-10 Issue:5336 Volume:278 Page:275-279
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mantyh Patrick W.¹²³⁴,Rogers Scott D.¹²³⁴,Honore Prisca¹²³⁴,Allen Brian J.¹²³⁴,Ghilardi Joseph R.¹²³⁴,Li Jun¹²³⁴,Daughters Randy S.¹²³⁴,Lappi Douglas A.¹²³⁴,Wiley Ronald G.¹²³⁴,Simone Donald A.¹²³⁴

Affiliation:

1. P. W. Mantyh, S. D. Rogers, P. Honore, B. J. Allen, J. R. Ghilardi, Molecular Neurobiology Laboratory (151), Veterans Administration Medical Center, Minneapolis, MN 55417; and Department of Preventive Sciences, School of Dentistry, University of Minnesota and the Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA.

2. J. Li, R. S. Daughters, D. A. Simone, Department of Preventive Sciences, School of Dentistry, University of Minnesota and the Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA.

3. D. A. Lappi, Advanced Targeting Systems, 1600 Faraday Avenue, Carlsbad, CA 92008, USA.

4. R. G. Wiley, Neurology Service (147), Veterans Administration Medical Center, Nashville, TN 37212, USA.

Abstract

Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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