Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells-Reference-Cited by-同舟云学术

Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells

Published:1997-10-10 Issue:5336 Volume:278 Page:283-286
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Moody D. Branch¹²³⁴,Reinhold Bruce B.¹²³⁴,Guy Mark R.¹²³⁴,Beckman Evan M.¹²³⁴,Frederique Daphney E.¹²³⁴,Furlong Stephen T.¹²³⁴,Ye Song¹²³⁴,Reinhold Vernon N.¹²³⁴,Sieling Peter A.¹²³⁴,Modlin Robert L.¹²³⁴,Besra Gurdyal S.¹²³⁴,Porcelli Steven A.¹²³⁴

Affiliation:

1. D. B. Moody, E. M. Beckman, D. E. Frederique, S. T. Furlong, S.A. Porcelli, Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

2. B. B. Reinhold, S. Ye, V. N. Reinhold, Mass Spectrometry Unit, Boston University School of Medicine, Boston, MA 02118–2394, USA.

3. M. R. Guy and G. S. Besra, Department of Microbiology, Colorado State University, Fort Collins, CO 80523–1677, USA.

4. P.A. Sieling and R. L. Modlin, Division of Dermatology and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90033, USA.

Abstract

The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM) as a CD1b-presented glycolipid allowed determination of the structural requirements for its recognition by T cells. Presentation of GMM to CD1b-restricted T cells was not affected by substantial variations in its lipid tails, but was extremely sensitive to chemical alterations in its carbohydrate or other polar substituents. These findings support the view that the recently demonstrated hydrophobic CD1 groove binds the acyl chains of lipid antigens relatively nonspecifically, thereby positioning the hydrophilic components for highly specific interactions with T cell antigen receptors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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