1. Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
2. Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
3. Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA.
4. Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
5. Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.