Comment on “Circadian rhythms in the absence of the clock gene Bmal1 ”-Reference-Cited by-同舟云学术

Comment on “Circadian rhythms in the absence of the clock gene Bmal1 ”

Published:2021-04-16 Issue:6539 Volume:372 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ness-Cohn Elan¹²^ORCID,Allada Ravi²³^ORCID,Braun Rosemary¹²⁴⁵^ORCID

Affiliation:

1. Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.

2. NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA.

3. Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.

4. Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA.

5. Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.

Abstract

Ray et al . (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1 .

Funder

NSF Office of the Director

Simons Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference11 articles.

1. Circadian rhythms in the absence of the clock gene Bmal1

2. Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

3. Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus

4. Detecting Rhythms in Time Series with RAIN

5. Signals from Chloroplasts Converge to Regulate Nuclear Gene Expression

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