Affiliation:
1. Department of Chemistry, Columbia University, New York, NY 10027, USA.
Abstract
Competition for binaphthyl catalysts
The binaphthyl framework has proven extremely effective in biasing a broad range of chemical reactions toward just one of two mirror-image products. The motif was first applied as a ligand in metal catalysis, and more recently as a conjugate base in acid catalysis. Gheewala
et al.
report a class of chiral carbon acids based around a cyclopentadiene framework that are easily accessible from readily available precursors. The compounds are showcased as highly selective catalysts for asymmetric Mukaiyama Mannich and oxocarbenium aldol reactions.
Science
, this issue p.
961
Funder
National Science Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
123 articles.
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