Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81-Reference-Cited by-同舟云学术

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

Published:2013-08-30 Issue:6149 Volume:341 Page:1009-1012
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bhogaraju Sagar¹,Cajanek Lukas²,Fort Cécile³,Blisnick Thierry³,Weber Kristina¹,Taschner Michael¹,Mizuno Naoko¹,Lamla Stefan⁴,Bastin Philippe³,Nigg Erich A.²,Lorentzen Esben¹

Affiliation:

1. Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

2. Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

3. Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA2581, 25 Rue du Docteur Roux, 75015 Paris, France.

4. Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

Abstract

Cilium Conundrum The cilium has emerged as the antenna of eukaryotic cells, having numerous functions in sensory reception and developmental signaling. Several disorders, such as polycystic kidney disease, are the result of compromised cilia structure. Bhogaraju et al. (p. 1009 ) elucidate how the intraflagellar transport machinery recognizes tubulin, a ciliary cargo that is integral to cilium maintenance and formation and is constantly turned over at the cilium tip.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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