Molecular mechanism of cytokinin-activated cell division in Arabidopsis

Author:

Yang Weibing1ORCID,Cortijo Sandra1ORCID,Korsbo Niklas12ORCID,Roszak Pawel1ORCID,Schiessl Katharina1ORCID,Gurzadyan Aram12ORCID,Wightman Raymond1ORCID,Jönsson Henrik123ORCID,Meyerowitz Elliot14ORCID

Affiliation:

1. Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK.

2. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK.

3. Department of Astronomy and Theoretical Physics, Lund University, SE22362 Lund, Sweden.

4. Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

Abstract

Cell cycle regulation The hormone cytokinin regulates various aspects of plant development and physiology, largely by managing cell proliferation. Yang et al. show that cytokinin promotes nuclear localization of the transcription factor MYB3R4, which activates the expression of two importins and genes that tip the cell into the next phase of the cell cycle. The importins facilitate further MYB3R4 accumulation within the nucleus, accelerating the progression into mitosis. MYB3R4 and the importins dissipate when the nuclear membrane dissolves at prometaphase, so there is only one round of mitotic activation per cell cycle. Science , this issue p. 1350

Funder

Howard Hughes Medical Institute

Leverhulme Trust

Gatsby Charitable Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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