Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Author:

Hirose Kentaro12ORCID,Payumo Alexander Y.12ORCID,Cutie Stephen12ORCID,Hoang Alison12,Zhang Hao3,Guyot Romain4ORCID,Lunn Dominic12ORCID,Bigley Rachel B.12,Yu Hongyao5,Wang Jiajia5,Smith Megan6ORCID,Gillett Ellen7ORCID,Muroy Sandra E.8ORCID,Schmid Tobias9,Wilson Emily3,Field Kenneth A.10ORCID,Reeder DeeAnn M.10ORCID,Maden Malcom11ORCID,Yartsev Michael M.9ORCID,Wolfgang Michael J.12,Grützner Frank7,Scanlan Thomas S.13,Szweda Luke I.14,Buffenstein Rochelle6ORCID,Hu Guang5,Flamant Frederic4ORCID,Olgin Jeffrey E.13,Huang Guo N.12ORCID

Affiliation:

1. Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA.

3. Department of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, CA 94158, USA.

4. Department of Internal Medicine, Institut de Génomique Fonctionnelle de Lyon, Institut National de la Recherche Agronomique, Université Lyon 1, CNRS, École Normale Superieure de Lyon, 69 007 France.

5. Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

6. Calico Life Sciences, 1170 Veterans Boulevard, South San Francisco, CA 94080, USA.

7. School of Biological Sciences, University of Adelaide, South Australia, Adelaide 5005, Australia.

8. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA.

9. Helen Wills Neuroscience Institute and Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94708, USA.

10. Department of Biology, Bucknell University, Lewisburg, PA 17837, USA.

11. Department of Biology and UF Genetics Institute, University of Florida, Gainesville, FL 32611, USA.

12. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

13. Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

14. Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.

Abstract

The price of staying warm Among vertebrates, zebrafish and salamanders can regenerate their hearts, whereas adult mice and humans cannot. Hirose et al. analyzed diploid cardiomyocyte frequency as a proxy for cardiac regenerative potential across 41 vertebrate species (see the Perspective by Marchianò and Murry). They observed an inverse correlation of these cells with thyroid hormone concentrations during the ectotherm-to-endotherm transition. Mice with defects in thyroid hormone signaling retained significant heart regenerative capacity, whereas zebrafish exposed to excessive thyroid hormones exhibit impaired cardiac repair. Loss of heart regenerative ability in mammals may represent a trade-off for increases in metabolism necessary for the development of endothermy. Science , this issue p. 184 ; see also p. 123

Funder

National Heart, Lung, and Blood Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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