Functional MRI of Macaque Monkeys Performing a Cognitive Set-Shifting Task-Reference-Cited by-同舟云学术

Functional MRI of Macaque Monkeys Performing a Cognitive Set-Shifting Task

Published:2002-02-22 Issue:5559 Volume:295 Page:1532-1536
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nakahara Kiyoshi¹,Hayashi Toshihiro¹²,Konishi Seiki¹,Miyashita Yasushi¹³

Affiliation:

1. Department of Physiology,

2. Department of Neurology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

3. National Institute for Physiological Sciences, Myodaiji-cho, Okazaki 444-8585, Japan.

Abstract

Functional brain organization of macaque monkeys and humans was directly compared by functional magnetic resonance imaging. Subjects of both species performed a modified Wisconsin Card Sorting Test that required behavioral flexibility in the form of cognitive set shifting. Equivalent visual stimuli and task sequence were used for the two species. We found transient activation related to cognitive set shifting in focal regions of prefrontal cortex in both monkeys and humans. These functional homologs were located in cytoarchitectonically equivalent regions in the posterior part of ventrolateral prefrontal cortex. This comparative imaging provides insights into the evolution of cognition in primates.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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