A Trypanosome Structure Involved in Transmitting Cytoplasmic Information During Cell Division-Reference-Cited by-同舟云学术

A Trypanosome Structure Involved in Transmitting Cytoplasmic Information During Cell Division

Published:2001-10-19 Issue:5542 Volume:294 Page:610-612
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Moreira-Leite Flávia F.¹,Sherwin Trevor¹,Kohl Linda¹,Gull Keith¹

Affiliation:

1. School of Biological Sciences, 2.205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

Abstract

African trypanosomes are protozoan parasites that cause sleeping sickness in humans through a tsetse fly vector. The procyclic form of Trypanosoma brucei has a single, attached flagellum that describes a helical path along the cell from posterior to anterior. During division, a specific flagellum-flagellum connection is elaborated between the new and old flagellum. This connector was present only during cell duplication and was found to be involved in the replication of the helical cell pattern and polarity. This finding implicates the concept of cytotaxis in cell morphogenesis in trypanosomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. Procyclic T. brucei brucei (427 strain) cells were cultivated and prepared for SEM and TEM essentially as described (22). Subpellicular microtubules were removed by treatment of samples with 60 mM CaCl 2 for 1 min immediately after detergent extraction and before fixation. Preparations were observed in a Cambridge Stereoscan 360 at 15 kV for SEM and in a Philips EM400T for TEM.

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