Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception-Reference-Cited by-同舟云学术

Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception

Published:2020-06-19 Issue:6497 Volume:368 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Neubarth Nicole L.¹²^ORCID,Emanuel Alan J.¹²^ORCID,Liu Yin³⁴^ORCID,Springel Mark W.¹²^ORCID,Handler Annie¹²^ORCID,Zhang Qiyu¹²^ORCID,Lehnert Brendan P.¹²^ORCID,Guo Chong¹^ORCID,Orefice Lauren L.¹²^ORCID,Abdelaziz Amira¹²^ORCID,DeLisle Michelle M.¹²^ORCID,Iskols Michael¹²^ORCID,Rhyins Julia¹²^ORCID,Kim Soo J.¹²,Cattel Stuart J.¹²,Regehr Wade¹^ORCID,Harvey Christopher D.¹^ORCID,Drugowitsch Jan¹^ORCID,Ginty David D.¹²^ORCID

Affiliation:

1. Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

2. Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

3. Department of Biochemistry, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA.

4. Howard Hughes Medical Institute, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA.

Abstract

Secrets of Meissner corpuscles The Meissner corpuscle, a mechanosensory end organ, was discovered more than 165 years ago and has since been found in the glabrous skin of all mammals, including that on human fingertips. Although prominently featured in textbooks, the function of the Meissner corpuscle is unknown. Neubarth et al. generated adult mice without Meissner corpuscles and used them to show that these corpuscles alone mediate behavioral responses to, and perception of, gentle forces (see the Perspective by Marshall and Patapoutian). Each Meissner corpuscle is innervated by two molecularly distinct, yet physiologically similar, mechanosensory neurons. These two neuronal subtypes are developmentally interdependent and their endings are intertwined within the corpuscle. Both Meissner mechanosensory neuron subtypes are homotypically tiled, ensuring uniform and complete coverage of the skin, yet their receptive fields are overlapping and offset with respect to each other. Science , this issue p. eabb2751 ; see also p. 1311

Funder

National Science Foundation

Howard Hughes Medical Institute

National Institute of Mental Health

NIH Office of the Director

National Institute of Neurological Disorders and Stroke

James S. McDonnell Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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