Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India
Author:
Dhar Mahesh S.1ORCID, Marwal Robin1ORCID, VS Radhakrishnan1ORCID, Ponnusamy Kalaiarasan1ORCID, Jolly Bani23ORCID, Bhoyar Rahul C.2ORCID, Sardana Viren23ORCID, Naushin Salwa23ORCID, Rophina Mercy23, Mellan Thomas A.4ORCID, Mishra Swapnil4ORCID, Whittaker Charles4ORCID, Fatihi Saman23ORCID, Datta Meena1, Singh Priyanka1ORCID, Sharma Uma1ORCID, Ujjainiya Rajat23ORCID, Bhatheja Nitin2ORCID, Divakar Mohit Kumar23ORCID, Singh Manoj K.1ORCID, Imran Mohamed23, Senthivel Vigneshwar23, Maurya Ranjeet23ORCID, Jha Neha2ORCID, Mehta Priyanka2ORCID, A Vivekanand23ORCID, Sharma Pooja23ORCID, VR Arvinden23ORCID, Chaudhary Urmila1, Soni Namita1, Thukral Lipi23ORCID, Flaxman Seth5ORCID, Bhatt Samir46ORCID, Pandey Rajesh23ORCID, Dash Debasis23ORCID, Faruq Mohammed23ORCID, Lall Hemlata1ORCID, Gogia Hema1, Madan Preeti1ORCID, Kulkarni Sanket1ORCID, Chauhan Himanshu1, Sengupta Shantanu23ORCID, Kabra Sandhya1, Gupta Ravindra K.78ORCID, Singh Sujeet K.1, Agrawal Anurag23ORCID, Rakshit Partha1ORCID, Nandicoori Vinay, Tallapaka Karthik Bharadwaj, Sowpati Divya Tej, Thangaraj K., Bashyam Murali Dharan, Dalal Ashwin, Sivasubbu Sridhar, Scaria Vinod, Parida Ajay, Raghav Sunil K., Prasad Punit, Sarin Apurva, Mayor Satyajit, Ramakrishnan Uma, Palakodeti Dasaradhi, Seshasayee Aswin Sai Narain, Bhat Manoj, Shouche Yogesh, Pillai Ajay, Dikid Tanzin, Das Saumitra, Maitra Arindam, Chinnaswamy Sreedhar, Biswas Nidhan Kumar, Desai Anita Sudhir, Pattabiraman Chitra, Manjunatha M. V., Mani Reeta S., Arunachal Udupi Gautam, Abraham Priya, Atul Potdar Varsha, Cherian Sarah S.,
Affiliation:
1. National Centre for Disease Control, Delhi, India. 2. CSIR-Institute of Genomics and Integrative Biology, New Delhi, India. 3. Academy for Scientific and Innovative Research, Ghaziabad, India. 4. Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK. 5. Department of Mathematics, Imperial College London, London, UK. 6. Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 7. Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. 8. Africa Health Research Institute, KwaZulu-Natal, South Africa.
Abstract
Deadly surge in Delhi
In the spring of 2021, Delhi, India experienced a wave of coronavirus cases that overwhelmed healthcare services despite the population showing a high level of immune positivity. Dhar
et al
. collated a mixture of serosurveillance, quantitative polymerase chain reaction, and genomic data, finding that waves of variants had passed through the Delhi population during 2020 and 2021. The alpha (B.1.1.7) variant dominated in March 2021 and was rapidly replaced by the delta (B.1.617.2) variant in April and May 2021. The delta variant outcompeted its predecessors by mutations that enhanced replication, immune evasion, and host receptor avidity, thus increasing transmissibility, reinfection, and vaccination breakthrough. —CA
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference42 articles.
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