Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition-Reference-Cited by-同舟云学术

Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition

Published:2016-01-08 Issue:6269 Volume:351 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Basu Jayeeta¹,Zaremba Jeffrey D.¹,Cheung Stephanie K.¹,Hitti Frederick L.¹,Zemelman Boris V.²,Losonczy Attila¹,Siegelbaum Steven A.¹

Affiliation:

1. Department of Neuroscience, Kavli Brain Institute, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA.

2. University of Texas at Austin, Austin, TX 78712, USA.

Abstract

Fine-tuned information flow in the brain In addition to providing well-characterized excitatory inputs, the entorhinal cortex also sends long-range inhibitory projections to the hippocampus. Basu et al. described this input in detail and characterized its role for learning and memory. Multimodal sensory stimuli activate long-range inhibitory input in vivo. This input enables precisely timed information transfer within the cortico-hippocampal circuit. In this way, long-range inhibitory projections play an important role in providing specificity of fear conditioning, and thus help prevent overgeneralization. Science , this issue p. 10.1126/science.aaa5694

Funder

NARSAD

National Institute of Mental Health (NIMH)

NIMH

Searle Scholars Program

Human Frontier Science Program

McKnight Memory and Cognitive Disorders Award

National Institute of Neurological Disorders and Stroke

NIH

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)