A single cell atlas of sexual development in Plasmodium falciparum

Author:

Dogga Sunil Kumar1ORCID,Rop Jesse C.1ORCID,Cudini Juliana1,Farr Elias12ORCID,Dara Antoine3,Ouologuem Dinkorma3ORCID,Djimdé Abdoulaye A.3ORCID,Talman Arthur M.4ORCID,Lawniczak Mara K. N.1ORCID

Affiliation:

1. Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

2. Institute for Computational Biomedicine, University of Heidelberg, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.

3. Malaria Research and Training Center (MRTC), Faculty of Pharmacy, Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Point G, P.O. Box, 1805 Bamako, Mali.

4. MIVEGEC, University of Montpellier, IRD, CNRS, Montpellier, France.

Abstract

The developmental decision made by malaria parasites to become sexual underlies all malaria transmission. Here, we describe a rich atlas of short- and long-read single-cell transcriptomes of over 37,000 Plasmodium falciparum cells across intraerythrocytic asexual and sexual development. We used the atlas to explore transcriptional modules and exon usage along sexual development and expanded it to include malaria parasites collected from four Malian individuals naturally infected with multiple P. falciparum strains. We investigated genotypic and transcriptional heterogeneity within and among these wild strains at the single-cell level, finding differential expression between different strains even within the same host. These data are a key addition to the Malaria Cell Atlas interactive data resource, enabling a deeper understanding of the biology and diversity of transmission stages.

Publisher

American Association for the Advancement of Science (AAAS)

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