Role of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity-Reference-Cited by-同舟云学术

Role of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity

Published:1999-01-15 Issue:5400 Volume:283 Page:397-401
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gainetdinov Raul R.¹,Wetsel William C.¹,Jones Sara R.¹,Levin Edward D.¹,Jaber Mohamed¹,Caron Marc G.¹

Affiliation:

1. R. R. Gainetdinov, S. R. Jones, M. Jaber, M. G. Caron, Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA. W. C. Wetsel, Departments of Psychiatry and Medicine (Endocrinology), Duke University Medical Center, Durham, NC 27710, USA. E. D. Levin, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

The mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice lacking the gene encoding the plasma membrane dopamine transporter (DAT) have elevated dopaminergic tone and are hyperactive. This activity was exacerbated by exposure to a novel environment. Additionally, these mice were impaired in spatial cognitive function, and they showed a decrease in locomotion in response to psychostimulants. This paradoxical calming effect of psychostimulants depended on serotonergic neurotransmission. The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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