Continuous Particle Separation Through Deterministic Lateral Displacement-Reference-Cited by-同舟云学术

Continuous Particle Separation Through Deterministic Lateral Displacement

Published:2004-05-14 Issue:5673 Volume:304 Page:987-990
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Huang Lotien Richard¹²³,Cox Edward C.¹²³,Austin Robert H.¹²³,Sturm James C.¹²³

Affiliation:

1. Department of Electrical Engineering, Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ 08544, USA.

2. Department of Molecular Biology, Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ 08544, USA.

3. Department of Physics, Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ 08544, USA.

Abstract

We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40seconds with a resolution of ∼10nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of ∼12%.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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