Requirement for γδ T Cells in Allergic Airway Inflammation-Reference-Cited by-同舟云学术

Requirement for γδ T Cells in Allergic Airway Inflammation

Published:1998-05-22 Issue:5367 Volume:280 Page:1265-1267
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zuany-Amorim Claudia¹²³,Ruffié Claude¹²³,Hailé Solomon¹²³,Vargaftig B. Boris¹²³,Pereira Pablo¹²³,Pretolani Marina¹²³

Affiliation:

1. C. Zuany-Amorim, C. Ruffié, B. B. Vargaftig, M. Pretolani, Unité de Pharmacologie Cellulaire, UnitéAssociée Institut Pasteur/INSERM U485, Paris, France.

2. P. Pereira, Unité d'Immunobiologie, CNRS URA 1961, Institut Pasteur, Paris, France.

3. S. Hailé, Unité d'Histopathologie, Institut Pasteur, Paris, France.

Abstract

The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (T H 2) cell response. In a model of pulmonary allergic inflammation, mice that lacked γδ T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to γδ T cell-deficient mice during the primary immunization. Thus, γδ T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for T H 2-mediated airway inflammation to peptidic antigens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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