Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud-Reference-Cited by-同舟云学术

Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud

Published:1998-05-22 Issue:5367 Volume:280 Page:1274-1277
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kengaku Mineko¹²³,Capdevila Javier¹²³,Rodriguez-Esteban Concepción¹²³,De La Peña Jennifer¹²³,Johnson Randy L.¹²³,Belmonte Juan Carlos Izpisúa¹²³,Tabin Clifford J.¹²³

Affiliation:

1. M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

2. J. Capdevila, C. Rodriguez-Esteban, J. De La Peña, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

3. R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Abstract

The apical ectodermal ridge (AER) is an essential structure for vertebrate limb development. Wnt3a is expressed during the induction of the chick AER, and misexpression of Wnt3a induces ectopic expression of AER-specific genes in the limb ectoderm. The genes β -catenin and Lef1 can mimic the effect of Wnt3a , and blocking the intrinsic Lef1 activity disrupts AER formation. Hence, Wnt3a functions in AER formation through the β-catenin/LEF1 pathway. In contrast, neither β -catenin nor Lef1 affects the Wnt7a -regulated dorsoventral polarity of the limb. Thus, two related Wnt genes elicit distinct responses in the same tissues by using different intracellular pathways.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference37 articles.

1. Molecular Models for Vertebrate Limb Development

2. Kengaku M., Twombly V., Tabin C., Cold Spring Harbor Symp. Quant. Biol.L12, 421 (1998); Y. Yang and A. McMahon, personal communication.

3. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

4. Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

5. See supplementary figures at http://www.sciencemag.org/feature/data/976400.shl.

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