Vitamin D regulates microbiome-dependent cancer immunity-Reference-Cited by-同舟云学术

Vitamin D regulates microbiome-dependent cancer immunity

Published:2024-04-26 Issue:6694 Volume:384 Page:428-437
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Giampazolias Evangelos¹²,Pereira da Costa Mariana¹^ORCID,Lam Khiem C.³^ORCID,Lim Kok Haw Jonathan¹⁴^ORCID,Cardoso Ana¹^ORCID,Piot Cécile¹^ORCID,Chakravarty Probir⁵^ORCID,Blasche Sonja⁶^ORCID,Patel Swara²^ORCID,Biram Adi¹^ORCID,Castro-Dopico Tomas¹^ORCID,Buck Michael D.¹^ORCID,Rodrigues Richard R.⁷⁸^ORCID,Poulsen Gry Juul⁹^ORCID,Palma-Duran Susana A.¹⁰^ORCID,Rogers Neil C.¹^ORCID,Koufaki Maria A.¹¹^ORCID,Minutti Carlos M.¹^ORCID,Wang Pengbo²,Vdovin Alexander²^ORCID,Frederico Bruno¹^ORCID,Childs Eleanor¹^ORCID,Lee Sonia¹^ORCID,Simpson Ben¹²,Iseppon Andrea¹³^ORCID,Omenetti Sara¹³^ORCID,Kelly Gavin⁵^ORCID,Goldstone Robert⁵,Nye Emma¹⁴^ORCID,Suárez-Bonnet Alejandro¹⁴¹⁵^ORCID,Priestnall Simon L.¹⁴¹⁵^ORCID,MacRae James I.¹⁰^ORCID,Zelenay Santiago¹¹^ORCID,Patil Kiran Raosaheb⁶^ORCID,Litchfield Kevin¹²,Lee James C.¹⁶¹⁷^ORCID,Jess Tine⁹,Goldszmid Romina S.³^ORCID,Reis e Sousa Caetano¹^ORCID

Affiliation:

1. Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

2. Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

3. Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA.

4. Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK.

5. Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.

6. MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.

7. Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.

8. Microbiome and Genetics Core, LICI, CCR, NCI, Bethesda, MD 20892, USA.

9. National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark.

10. Metabolomics STP, The Francis Crick Institute, London NW1 1AT, UK.

11. Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

12. Tumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK.

13. AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

14. Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.

15. Department of Pathobiology and Population Sciences, The Royal Veterinary College, North Mimms, Hatfield, Hertfordshire AL9 7TA, UK.

16. Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

17. Institute of Liver and Digestive Health, Division of Medicine, Royal Free Hospital, University College London, London NW3 2QG, UK.

Abstract

A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis , which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adh7954

Reference80 articles.

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3. Vitamin D and immunity

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