The
Fusarium graminearum
Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization
Author:
Cuomo Christina A.12345, Güldener Ulrich12345, Xu Jin-Rong12345, Trail Frances12345, Turgeon B. Gillian12345, Di Pietro Antonio12345, Walton Jonathan D.12345, Ma Li-Jun12345, Baker Scott E.12345, Rep Martijn12345, Adam Gerhard12345, Antoniw John12345, Baldwin Thomas12345, Calvo Sarah12345, Chang Yueh-Long12345, DeCaprio David12345, Gale Liane R.12345, Gnerre Sante12345, Goswami Rubella S.12345, Hammond-Kosack Kim12345, Harris Linda J.12345, Hilburn Karen12345, Kennell John C.12345, Kroken Scott12345, Magnuson Jon K.12345, Mannhaupt Gertrud12345, Mauceli Evan12345, Mewes Hans-Werner12345, Mitterbauer Rudolf12345, Muehlbauer Gary12345, Münsterkötter Martin12345, Nelson David12345, O'Donnell Kerry12345, Ouellet Thérèse12345, Qi Weihong12345, Quesneville Hadi12345, Roncero M. Isabel G.12345, Seong Kye-Yong12345, Tetko Igor V.12345, Urban Martin12345, Waalwijk Cees12345, Ward Todd J.12345, Yao Jiqiang12345, Birren Bruce W.12345, Kistler H. Corby12345
Affiliation:
1. Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA. 2. Technische Universität München, Freising-Weihenstephan, Germany. 3. Institute for Bioinformatics, GSF National Research Center for Environment and Health, Neuherberg, Germany. 4. Purdue University, West Lafayette, IN 47907, USA. 5. Michigan State University, East Lansing, MI 48824, USA.
Abstract
We sequenced and annotated the genome of the filamentous fungus
Fusarium graminearum
, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of
F. graminearum
contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of
F. graminearum
with its plant hosts.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference18 articles.
1. The Fusarium Laboratory Manual 2006 2. R. S. Goswami, H. C. Kistler, Mol. Plant Pathol.5, 515 (2004). 3. J. W. Bennett, M. Kilch, Clin. Microbiol. Rev.16, 497 (2003). 4. D. C. Changet al., JAMA296, 953 (2006). 5. M. C. Dignani, E. Anaissie, Clin. Microbiol. Infect.10, (Suppl 1), 67 (2004).
Cited by
785 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|