Affiliation:
1. Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, and Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Abstract
Signaling hematopoietic stem cells from afar
Throughout our entire life span, hematopoietic stem cells (HSCs) generate all of our blood cells. The bone marrow microenvironment, or niche, is key to activating stem cell activity. Decker
et al.
now show that thrombopoietin generated in the liver, but not from the local bone marrow niche, maintains HSCs in vivo in mice. Thus, systemic endocrine factors are needed to maintain somatic stem cells from a distance. These findings may be important when considering how to stimulate HSCs for therapeutic use.
Science
, this issue p.
106
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
83 articles.
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