A critical time window for dopamine actions on the structural plasticity of dendritic spines-Reference-Cited by-同舟云学术

A critical time window for dopamine actions on the structural plasticity of dendritic spines

Published:2014-09-26 Issue:6204 Volume:345 Page:1616-1620
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yagishita Sho¹²,Hayashi-Takagi Akiko¹²³,Ellis-Davies Graham C.R.⁴,Urakubo Hidetoshi⁵,Ishii Shin⁵,Kasai Haruo¹²

Affiliation:

1. Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

2. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.

3. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.

4. Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

5. Integrated Systems Biology Laboratory, Department of Systems Science, Graduate School of Informatics, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

Abstract

Animal behavior follows rewards Animal behavior is learned and reinforced by rewards. On a molecular level, the reward comes in the form of the neurotransmitter, dopamine, which modulates synapses. The exact timing and mechanism of this process remain unknown. Using optical stimulation, Yagishita et al. found that dopaminergic modulation involved dendritic spine enlargement only during an extremely narrow time window. Known as reinforcement plasticity, this cellular basis for learning could provide insight into psychiatric disorders involving dopaminergic regulation, such as depression, drug addiction, and schizophrenia. Science , this issue p. 1616

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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