Response to Comment on “The Geometric Structure of the Brain Fiber Pathways”

Author:

Wedeen Van J.12,Rosene Douglas L.3,Wang Ruopeng1,Dai Guangping1,Mortazavi Farzad3,Hagmann Patric4,Kaas Jon H.5,Tseng Wen-Yih I.6

Affiliation:

1. Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Street, 2nd floor, Charlestown, MA 02129, USA.

2. Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, E25-519, Cambridge, MA 02139, USA.

3. Department of Anatomy and Neurobiology, Boston University Medical Campus, 700 Albany Street, W701, Boston, MA 02118, USA.

4. Department of Radiology, University Hospital Center and University of Lausanne (CHUV-UNL), Rue du Bugnon, 46, CH-1011 Lausanne, Switzerland.

5. Department of Psychology, College of Arts and Sciences, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37240, USA.

6. Department of Radiology, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, 1 Jen-Ai Road, Taipei, Sec 1, Taiwan 100.

Abstract

In response to Catani et al ., we show that corticospinal pathways adhere via sharp turns to two local grid orientations; that our studies have three times the diffusion resolution of those compared; and that the noted technical concerns, including crossing angles, do not challenge the evidence of mathematically specific geometric structure. Thus, the geometric thesis gives the best account of the available evidence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference14 articles.

1. Comment on “The Geometric Structure of the Brain Fiber Pathways”

2. The Geometric Structure of the Brain Fiber Pathways

3. W. J. S. Krieg Connections of the Frontal Cortex of the Monkey (Charles C. Thomas Springfield Il 1954) figures 37 and 96.

4. V. J. Wedeen et al . Proc. 1st Intl. Conf. Funct. Map. Human Brain P1 69 (1995).

5. Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers

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