Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes-Reference-Cited by-同舟云学术

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Published:2016-04-22 Issue:6284 Volume:352 Page:459-463
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mackay Laura K.¹²,Minnich Martina³,Kragten Natasja A. M.⁴,Liao Yang⁵⁶,Nota Benjamin⁷,Seillet Cyril⁵⁶,Zaid Ali¹,Man Kevin⁵⁶,Preston Simon⁵⁶,Freestone David¹,Braun Asolina¹,Wynne-Jones Erica¹,Behr Felix M.⁴⁵⁶⁸,Stark Regina⁴,Pellicci Daniel G.¹²,Godfrey Dale I.¹²,Belz Gabrielle T.⁵⁶,Pellegrini Marc⁵⁶,Gebhardt Thomas¹,Busslinger Meinrad³,Shi Wei⁵⁹,Carbone Francis R.¹,van Lier René A. W.⁴,Kallies Axel⁵⁶,van Gisbergen Klaas P. J. M.⁴⁵⁶⁸

Affiliation:

1. Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

2. Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Australia.

3. Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

4. Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, Netherlands.

5. The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

6. Department of Medical Biology, The University of Melbourne, Melbourne, Australia.

7. Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, AMC, University of Amsterdam, Amsterdam, Netherlands.

8. Department of Experimental Immunology, AMC, Amsterdam, Netherlands.

9. Department of Computing and Information Systems, The University of Melbourne, Melbourne, Australia.

Abstract

Transcription factors define tissue T cells The immune system fights microbial invaders by maintaining multiple lines of defense. For instance, specialized memory T cells [resident memory T cells (T rms )] colonize portals of pathogen entry, such as the skin, lung, and gut, to quickly halt reinfections. Mackay et al. now report that in mice, T rms as well as other tissue-dwelling lymphocyte populations such as natural killer cells share a common transcriptional program driven by the related transcription factors Hobit and Blimp1. Tissue residency and retention of lymphocytes require expression of Hobit and Blimp1, which, among other functions, suppress genes that promote tissue exit. Science , this issue p. 459

Funder

National Health and Medical Research Council of Australia (NHMRC)

Boehringer Ingelheim

European Research Council

European Community's Seventh Framework Programme

German Research Foundation

Alexander von Humboldt Foundation

Landsteiner Foundation of Blood Transfusion Research

NHMRC Early Career Fellowship

NHMRC Senior Principal Research Fellowship

ARC

Sylvia and Charles Viertel Foundation