Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

Author:

Soon Fen-Fen12,Ng Ley-Moy12,Zhou X. Edward1,West Graham M.3,Kovach Amanda1,Tan M. H. Eileen12,Suino-Powell Kelly M.1,He Yuanzheng1,Xu Yong1,Chalmers Michael J.3,Brunzelle Joseph S.4,Zhang Huiming5,Yang Huaiyu6,Jiang Hualiang6,Li Jun12,Yong Eu-Leong2,Cutler Sean7,Zhu Jian-Kang5,Griffin Patrick R.3,Melcher Karsten1,Xu H. Eric18

Affiliation:

1. Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.

2. Department of Obstetrics and Gynecology, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 119228.

3. Department of Molecular Therapeutics, Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way No. 2A2, Jupiter, FL 33458, USA.

4. Department of Molecular Pharmacology and Biological Chemistry, Life Sciences Collaborative Access Team (LS-CAT), Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.

5. Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA.

6. Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

7. Department of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, USA.

8. VARI-SIMM Center, Center for Structure and Function of Drug Targets, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China.

Abstract

Musical Chairs The plant hormone abscisic acid (ABA) helps plants to respond to changes in the environment, such as drought. Physiological responses are initiated when ABA binds to its receptor. In the absence of ABA, downstream kinases are held inactive by phosphatases. Soon et al. (p. 85 , published online 24 November; see the Perspective by Leung ) now show that both the hormone-receptor complex and the downstream kinase bind to the same site on the phosphatase. Thus, in the presence of hormone, the phosphatase is occupied and unable to interfere with downstream kinase activity.

Funder

National Institutes of Health

Office of Science

National Science Foundation

National Institute for General Medical Studies

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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