Targeting cancer with molecular glues-Reference-Cited by-同舟云学术

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Targeting cancer with molecular glues

Published:2023-08-18 Issue:6659 Volume:381 Page:729-730
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Liu Jun O.¹²³

Affiliation:

1. Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

2. Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

3. The SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Abstract

Molecular glues suppress the active form of the oncogenic protein KRAS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adj1001

Reference15 articles.

1. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

2. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

3. Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

4. Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

5. Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

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