Gate control of mechanical itch by a subpopulation of spinal cord interneurons-Reference-Cited by-同舟云学术

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

Published:2015-10-30 Issue:6260 Volume:350 Page:550-554
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bourane Steeve¹,Duan Bo²,Koch Stephanie C.¹,Dalet Antoine¹,Britz Olivier¹,Garcia-Campmany Lidia¹,Kim Euiseok³,Cheng Longzhen²⁴,Ghosh Anirvan³,Ma Qiufu²,Goulding Martyn¹

Affiliation:

1. Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

3. Neurobiology Section, Division of Biological Sciences, University of California, San Diego, CA 92093, USA.

4. Institute of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China.

Abstract

A circuit controlling mechanical itch Considerable progress has been made in understanding and treating chemically induced itch. However, little is known about the mechanisms underlying mechanically evoked itch. Bourane et al. produced a model of mechanical itch by reducing the number of neuropeptide Y–expressing inhibitory spinal interneurons. This led to a selective increase in mechanically evoked itch-like behavior in mice. In contrast, chemically evoked itch or pain behavior remained unaffected. Science , this issue p. 550

Funder

NIH

Gatsby Charitable Foundation

Caterina Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Neural processing of itch

2. Why we scratch an itch: the molecules, cells and circuits of itch

3. Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control