Promotion of Trophoblast Stem Cell Proliferation by FGF4-Reference-Cited by-同舟云学术

Promotion of Trophoblast Stem Cell Proliferation by FGF4

Published:1998-12-11 Issue:5396 Volume:282 Page:2072-2075
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tanaka Satoshi¹,Kunath Tilo¹,Hadjantonakis Anna-Katerina¹,Nagy Andras¹,Rossant Janet¹

Affiliation:

1. S. Tanaka and A.-K. Hadjantonakis, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. T. Kunath, A. Nagy, J. Rossant, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Abstract

The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

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2. Semin. Dev. Biol. 6 237 (1995).

3. Rossant J., Gardner R. L., Alexandre H. L., J. Embryol. Exp. Morphol. 48, 239 (1978);

4. Johnson M. H., Rossant J., ibid. 61, 103 (1981).

5. R. L. Gardner and M. H. Johnson ibid. 28 279 (1972)

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