Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”-Reference-Cited by-同舟云学术

Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

Published:2021-04-09 Issue:6538 Volume:372 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kamphuis Jasper B. J.¹^ORCID,Worrall William P. M.¹^ORCID,Stackowicz Julien²³,Mougel Aurélie¹^ORCID,Mauré Emilie¹^ORCID,Conde Eva²³^ORCID,Bruhns Pierre²^ORCID,Guilleminault Laurent¹⁴^ORCID,Gaudenzio Nicolas⁵^ORCID,Chen Jinmiao⁶^ORCID,Gentek Rebecca⁷^ORCID,Reber Laurent L.¹²^ORCID

Affiliation:

1. Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM U1291, University of Toulouse, CNRS U5282, 31024 Toulouse, France.

2. Unit of Antibodies in Therapy and Pathology, Institut Pasteur, UMR1222 INSERM, 75015 Paris, France.

3. Sorbonne Université, 75006 Paris, France.

4. Department of Respiratory Medicine, Toulouse University Hospital, Faculty of Medicine, 31059 Toulouse, France.

5. Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde (UDEAR), UMR 1056, INSERM, Université de Toulouse, 31059 Toulouse, France.

6. Singapore Immunology Network, Agency for Science, Technology and Research, 138648 Singapore.

7. Centre for Inflammation Research, University of Edinburgh, EH16 4TJ Edinburgh, UK.

Abstract

Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.

Funder

Kennedy Trust for Rheumatology Research

European Research Council

Institut national de la santé et de la recherche médicale

Institut Pasteur

Société Française de Dermatologie et de Pathologie Sexuellement Transmissible

Société Française d’Allergologie

Marie Skłodowska-Curie individual fellowship

Chancellor’s Fellowship of the University of Edinburgh

Publisher

American Association for the Advancement of Science (AAAS)

Subject